4-Chloro-2-pyridinecarbonitrile → 4-(4-Amino-2-fluorophenoxy)pyridine-2-carbonitrile

HRID 729937

Reaction equation

HRID 729937 reaction equation
NC1C=C(C=CC=1)O[C:6]1[CH:11]=[CH:10][N:9]=[C:8]([C:12]([NH2:14])=O)[CH:7]=1.[NH2:18][C:19]1[CH:24]=[CH:23][C:22]([OH:25])=[C:21]([F:26])[CH:20]=1.ClC1C=CN=C(C#N)C=1>>[NH2:18][C:19]1[CH:24]=[CH:23][C:22]([O:25][C:6]2[CH:11]=[CH:10][N:9]=[C:8]([C:12]#[N:14])[CH:7]=2)=[C:21]([F:26])[CH:20]=1

Participants

4

Reactant 3

HCID 6933424-Chloro-2-pyridinecarbonitrileHCID 2735918Phenol, 4-amino-2-fluoro-HCID 231372294-(3-Aminophenoxy)pyridine-2-carboxamide

Product 1

HCID 578332394-(4-Amino-2-fluorophenoxy)pyridine-2-carbonitrile

Procedure

4-(4-Amino-2-fluorophenoxy) pyridine-2-carbonitrile (2H) was prepared by a method analogous to that described for 4-(3-aminophenoxy) pyridine-2-carboxamide (2C), starting from 4-amino-2-fluorophenol and 4-chloro-2-cyanopyridine, MS ES: 230 (M+H)+, calcd 230, RT=2.18 min.

Sources & evidence

ORD record
ord-cc5abd50a961455fa1774767ea35f0fe
Source dataset
uspto-grants-2009_09
Patent number
US07582646B2

Linked notes

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