4-(2-Chloropyridin-4-yl)-5-(4-fluorophenyl)-1,3-dihydroimidazole-2-thione → 4-(4-Fluorophenyl)-5-(2-fluoropyridin-4-yl)-1,3-dihydroimidazole-2-thione

Reaction equation

Cl.[NH2:2][CH:3]([C:13]1[CH:18]=[CH:17][N:16]=[C:15]([F:19])[CH:14]=1)[C:4]([C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=1)=O.ClC1C=C(C2[NH:28][C:29](=[S:39])NC=2C2C=CC(F)=CC=2)C=CN=1>>[F:12][C:9]1[CH:10]=[CH:11][C:6]([C:4]2[NH:28][C:29](=[S:39])[NH:2][C:3]=2[C:13]2[CH:18]=[CH:17][N:16]=[C:15]([F:19])[CH:14]=2)=[CH:7][CH:8]=1

Participants

Reactant 2

HCID 108597274-(2-Chloropyridin-4-yl)-5-(4-fluorophenyl)-1,3-dihydroimidazole-2-thione

HCID 66811089HCID 66811089, compound

Product 1

HCID 110225724-(4-Fluorophenyl)-5-(2-fluoropyridin-4-yl)-1,3-dihydroimidazole-2-thione

Procedure

24b was prepared from 23b (6.1 g; 20 mmol) using the method described in the synthesis of 24a.

Sources & evidence

ORD record: ord-bc4d831c99b1445c8a11fddb9d9511de
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07582660B2

Reaction notes

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