HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → Ammonia
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Sulfuryl chloride | HCID 24648 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Sulfolane | HCID 31347 | — |
| Reactant | Benzenesulfonic acid, 2-amino-5-nitro- | HCID 66786 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Ammonia | HCID 222 | — |
| Product | 2-Amino-5-nitrobenzenesulfonamide | HCID 15358386 | — |
Reaction Steps
The commercially available sodium salt of 2-amino-5-nitro-benzenesulfonic acid can be converted to the corresponding sulfonyl chloride with phosphoryl chloride in the presence of a suitable co-solvent, such as sulfolane. Treatment with ammonia, e.g., ammonia solution in methanol or ammonia gas, affords the desired 2-amino-5-nitro-benzenesulfonamide intermediate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07582754B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-0531f833112e468eaba84e598a136d32 |
| Source note | uspto-grants-2009_09 |