Morpholine → 4-(4-Methylpiperidin-4-yl)morpholine
Reaction equation
C([N:8]1[CH2:13][CH2:12][C:11](O)([C:14]#N)[CH2:10][CH2:9]1)C1C=CC=CC=1.[NH:17]1[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1>CO>[CH3:14][C:11]1([N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 5.25 g (23.8 mmol) 1-benzyl-4-hydroxy-piperidine-4-carbonitrile and 2.2 mL (25.2 mmol) morpholine in 30 mL MeOH was refluxed for 6 h. The mixture was evaporated to dryness i. vac., while the product was obtained in the form of crystals.
Workup
- customThe mixture was evaporated to dryness i
- custom, while the product was obtained in the form of crystals
Sources & evidence
- ORD record
- ord-901a78f16963470fb68bb834f2476408
- Source dataset
- uspto-grants-2009_09
- Patent number
- US07582625B2
Reaction notes
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