tert-Butyl piperazine-1-carboxylate → Tert-butyl 4-(3-chloropyridin-4-yl)piperazine-1-carboxylate

HRID 730708Notes

Reaction equation

HRID 730708 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1Cl.[C:9]([O:13][C:14]([N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1)=[O:15])([CH3:12])([CH3:11])[CH3:10]>>[C:9]([O:13][C:14]([N:16]1[CH2:21][CH2:20][N:19]([C:7]2[CH:6]=[CH:5][N:4]=[CH:3][C:2]=2[Cl:1])[CH2:18][CH2:17]1)=[O:15])([CH3:12])([CH3:10])[CH3:11]

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 27360813,4-Dichloropyridine

Product 1

HCID 11558451Tert-butyl 4-(3-chloropyridin-4-yl)piperazine-1-carboxylate

Procedure

The pyridine from step (a) above (5 g, 3.38 mmol) and tert-butylpiperazinecarboxylate (6.29 g, 3.38 mmol, Aldrich) reacted under the conditions of Example 3a to give the title compound as an orange oil. MS (ESI, pos. ion) m/z: 298 (M+1).

Sources & evidence

ORD record
ord-732268ec5a8647c29b9c681af7cf45ba
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

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