3,5-Dichloro-2-fluoropyridine → Methyl 4-(N-(3,5-dichloropyridin-2-yl)-N-((1-methyl-1H-indazol-5-yl)methyl)sulfamoyl)-3-ethylbenzoate

HRID 73099Notes

Reaction equation

HRID 73099 reaction equation
[Cl:1][C:2]1[C:3](F)=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1.[CH2:10]([C:12]1[CH:13]=[C:14]([CH:19]=[CH:20][C:21]=1[S:22](=[O:36])(=[O:35])[NH:23][CH2:24][C:25]1[CH:26]=[C:27]2[C:31](=[CH:32][CH:33]=1)[N:30]([CH3:34])[N:29]=[CH:28]2)[C:15]([O:17][CH3:18])=[O:16])[CH3:11]>>[Cl:1][C:2]1[C:3]([N:23]([CH2:24][C:25]2[CH:26]=[C:27]3[C:31](=[CH:32][CH:33]=2)[N:30]([CH3:34])[N:29]=[CH:28]3)[S:22]([C:21]2[CH:20]=[CH:19][C:14]([C:15]([O:17][CH3:18])=[O:16])=[CH:13][C:12]=2[CH2:10][CH3:11])(=[O:36])=[O:35])=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1

Participants

3

Reactant 2

HCID 27832563,5-Dichloro-2-fluoropyridineHCID 66837911Methyl 3-ethyl-4-(N-((1-methyl-1H-indazol-5-yl)methyl)sulfamoyl)benzoate

Product 1

HCID 66837833Methyl 4-(N-(3,5-dichloropyridin-2-yl)-N-((1-methyl-1H-indazol-5-yl)methyl)sulfamoyl)-3-ethylbenzoate

Procedure

The titled compound was prepared according to the procedure described in step-2 of Example 1 from 3,5-dichloro-2-fluoropyridine and methyl 3-ethyl-4-(N-((1-methyl-1H-indazol-5-yl)methyl)sulfamoyl)benzoate (step-2 of Example 4).

Sources & evidence

ORD record
ord-c757065d212e4bdb83883c43ce310013
Source dataset
uspto-grants-2014_09
Patent number
US08829026B2

Reaction notes

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