HCID 58938153, compound → Benzoic acid, 3-fluoro-5-methyl-, methyl ester
Reaction equation
[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[C:8]([CH2:10]O)[CH:7]=[C:6]([F:12])[CH:5]=1>[Pd].C(O)C>[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[C:8]([CH3:10])[CH:7]=[C:6]([F:12])[CH:5]=1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
Ethanol (2 ml) was added to round bottom flask containing 3-fluoro-5-hydroxymethyl-benzoic acid methyl ester (667 mg, 3.6 mmol) and palladium (10 wt. % on activated carbon, 300 mg) under argon. The flask was evacuated using a water aspirator and then filled with hydrogen from a balloon. After stirring for 2 h, the palladium on carbon was removed by filtration through celite. The filtrate was then concentrated to afford 520 mg (87%) of 3-fluoro-5-methyl-benzoic acid methyl ester.
Workup
- customThe flask was evacuated
- additionfilled with hydrogen from a balloon
- customthe palladium on carbon was removed by filtration through celite
- concentrationThe filtrate was then concentrated
Sources & evidence
- ORD record
- ord-490167dca1644d7ebb184e9b083ee5fb
- Source dataset
- uspto-grants-2009_09
- Patent number
- US07585881B2
Reaction notes
Loading…