HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 733Generated: October 23, 2026
6-Hydroxymethylindole → HCID 70692775, compound
https://huagongshe.com/en/reaction/733
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 6-Hydroxymethylindole | HCID 2773459 | — |
| Reactant | 5-Chloro-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile | HCID 89827173 | — |
| Reagent | Cesium carbonate | HCID 10796 | — |
| Catalyst | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | HCID 70692775 | HCID 70692775 | 47.5% |
Reaction Steps
In a 40mL vial (t=g) was 5-chloro-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile (50 mg, 0.21 mmol), [Reactants], and cesium carbonate (77 mg, 0.24 mmol) in DMA (0.5 mL) ([VOLUME]),Pd2(dba)3 (9.80 mg, 10.70 µmol) and (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (12.38 mg, 0.02 mmol) were added. to give a brown suspension. The vial was filled with N2, 150C microwave for 30 min. LCMS showed completion. added MeOH (3 mL), filtered through celite. concentrated. The residue was purified by ISCO (Hexane to EtOAc:Hex=1;1 to EtOAc) to give about 34 mg offwhite solid
Provenance & Evidence
| Source dataset | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-e0d4157f08c0492097a16f50798a4aa4 |
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| Source note | 750 AstraZeneca ELN dataset |
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