4,6-Dichloro-2-methylpyrimidine → HCID 85836153, compound
Reaction equation
Cl[C:2]1[CH:7]=[C:6](Cl)[N:5]=[C:4]([CH3:9])[N:3]=1.[NH2:10][C:11]1[CH:12]=[C:13]([OH:21])[CH:14]=[C:15]([C:17]([F:20])([F:19])[F:18])[CH:16]=1>>[CH3:9][C:4]1[N:5]=[C:6]([NH:10][C:11]2[CH:16]=[C:15]([C:17]([F:18])([F:19])[F:20])[CH:14]=[C:13]([OH:21])[CH:12]=2)[CH:7]=[C:2]([NH:10][C:11]2[CH:16]=[C:15]([C:17]([F:18])([F:19])[F:20])[CH:14]=[C:13]([OH:21])[CH:12]=2)[N:3]=1Participants
3
Procedure
This compound was obtained (yield 43%) based on the method described in Production Example 2B using 4,6-dichloro-2-methylpyrimidine instead of the 4,6-dichloro-2-ethylpyrimidine, and using 3-amino-5-trifluoromethyl-phenol instead of the 3-aminophenol.
Workup
- customThis compound was obtained (yield 43%)
Sources & evidence
- ORD record
- ord-3788bef91f0546328a236145ce620677