Acetic Anhydride → 5-(Trifluoromethyl)isobenzofuran-1,3-dione
Reaction equation
[F:1][C:2]([F:16])([F:15])[C:3]1[CH:4]=[C:5]([C:12]([OH:14])=[O:13])[C:6](=[CH:10][CH:11]=1)[C:7](O)=[O:8].C(OC(=O)C)(=O)C>CC(O)=O>[F:1][C:2]([F:16])([F:15])[C:3]1[CH:4]=[C:5]2[C:6](=[CH:10][CH:11]=1)[C:7](=[O:8])[O:13][C:12]2=[O:14]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
25.0 g of 4-trifluoromethyl-phthalic acid were dissolved in 50 ml of HOAc and 15.1 ml of acetic anhydride added. The mixture was refluxed for 6 h. The solvent was then removed in vacuo. The residue was treated three times with 50 ml of toluene each followed by the removal of the solvent in vacuo. Yield 23.1 g of a colorless oil (Rf(CH2Cl2)=0.60).
Workup
- temperatureThe mixture was refluxed for 6 h
- customThe solvent was then removed in vacuo
- additionThe residue was treated three times with 50 ml of toluene
- customeach followed by the removal of the solvent in vacuo
Sources & evidence
- ORD record
- ord-dba24d8a2a644929bcb024ae3e0cc8e6
- Source dataset
- uspto-grants-2009_09
- Patent number
- US07589117B2
Reaction notes
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