HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 7334Generated: October 26, 2026
1-Bromo-4-iodobenzene → 1-Bromo-2',3'-difluoro-4'-ethoxybiphenyl
https://huagongshe.com/reaction/7334
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Bromo-4-iodobenzene | HCID 11522 | — |
| Reactant | Sodium metaborate | HCID 145326 | — |
| Reactant | B-(4-Ethoxy-2,3-difluorophenyl)boronic acid | HCID 15135235 | — |
| Reactant | Hydrazinium hydrochloride | HCID 21989311 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-Bromo-2',3'-difluoro-4'-ethoxybiphenyl | HCID 21989312 | — |
Reaction Steps
0.450 mol of sodium metaborate are introduced into 240 ml of water. 0.012 mol of bis(triphenylphosphine)palladium(II) chloride, 0.6 mol of 4-bromo-1-iodobenzene (11) and 0.012 mol of hydrazinium hydrochloride are added, and the mixture is stirred at about 20° C. for 5 minutes. 0.6 mol of 2,3-difluoro-4-ethoxyphenylboronic acid (12) dissolved in 600 ml of tetrahydrofuran are then added, and the mixture is refluxed for 4 hours, giving the compound of the formula 13.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07087272B2 |
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| Source dataset | uspto-grants-2006_08 |
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| ORD ID | ord-eca79e3229d14634afded7b73fa277ff |
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| Source note | uspto-grants-2006_08 |
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