3,5-Dimethylisoxazole-4-sulfonyl chloride → HCID 53492155, compound

HRID 73401

Reaction equation

HRID 73401 reaction equation
[F:1][C:2]1[C:7]([F:8])=[C:6]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([I:16])=[CH:12][C:11]=2[F:17])[C:5]([NH2:18])=[CH:4][CH:3]=1.[CH3:19][C:20]1[C:24]([S:25](Cl)(=[O:27])=[O:26])=[C:23]([CH3:29])[O:22][N:21]=1>>[F:8][C:7]1[C:6]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([I:16])=[CH:12][C:11]=2[F:17])=[C:5]([NH:18][S:25]([C:24]2[C:20]([CH3:19])=[N:21][O:22][C:23]=2[CH3:29])(=[O:27])=[O:26])[CH:4]=[CH:3][C:2]=1[F:1]

Participants

3

Reactant 2

HCID 27363193,5-Dimethylisoxazole-4-sulfonyl chlorideHCID 593863065,6-difluoro-N1-(2-fluoro-4-iodophenyl)benzene-1,2-diamine

Product 1

HCID 53492155HCID 53492155, compound

Procedure

According to the general procedure B, 5,6-difluoro-N1-(2-fluoro-4-iodophenyl)benzene-1,2-diamine (0.182 mmol) was reacted with 3,5-dimethylisoxazole-4-sulfonyl chloride (0.5 mmol) to obtain N-(3,4-difluoro-2-(2-fluoro-4-iodophenyl amino)phenyl)-3,5dimethylisoxazole-4-sulfonamide. 1H NMR (300 MHz, CDCl3)) δ 2.2 (s, 3H), 2.4 (s, 3H), 5.8 (s, 1H), 6.0 (dt, 1H), 5.95 (s, 1H), 6.9 (s, 1H), 7.0 (q, 1H), 7.2 (m, 3H), 7.4 (dd, 1H).

Sources & evidence

ORD record
ord-22d8cec2e7294fc49ab0f9f6d2736940
Source dataset
uspto-grants-2014_09
Patent number
US08829052B2

Linked notes

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