HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromothiophene-2-sulfonyl chloride → 5-Bromo-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl)thiophene-2-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromothiophene-2-sulfonyl chloride | HCID 2733924 | — |
| Reactant | 5,6-difluoro-N1-(2-fluoro-4-iodophenyl)benzene-1,2-diamine | HCID 59386306 | — |
| Product | 5-Bromo-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl)thiophene-2-sulfonamide | HCID 59386377 | — |
Reaction Steps
According to the general procedure B, 5,6-difluoro-N1-(2-fluoro-4-iodophenyl)benzene1,2-diamine was reacted with 5-bromothiophene-2-sulfonyl chloride to obtain the title compound. 1H NMR (300 MHz, CDCl3): δ 7.39-7.29 (m, 2H), 7.20-7.05 (m, 3H), 6.96 (d, J=3.6 Hz, 1H), 5.85(dt, J=2.1, 9.0 & 17.4 Hz, 1H), 5.54 (br s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08829052B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-e6a4ea04a9b041ceb77b7df1c8d4886b |
| Source note | uspto-grants-2014_09 |