Cesium carbonate → {2-[1-(2,3-Dimethylphenyl)ethyl]-1h-imidazol-1-yl}methyl propionate

HRID 734452

Reaction equation

HRID 734452 reaction equation
[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:9]([C:11]1[NH:12][CH:13]=[CH:14][N:15]=1)[CH3:10].C(=O)([O-])[O-].[Cs+].[Cs+].[C:22]([O:26][CH2:27]Cl)(=[O:25])[CH2:23][CH3:24]>CC(C)=O>[C:22]([O:26][CH2:27][N:15]1[CH:14]=[CH:13][N:12]=[C:11]1[CH:9]([C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([CH3:8])[C:2]=1[CH3:1])[CH3:10])(=[O:25])[CH2:23][CH3:24]

Participants

5

Reactant 3

HCID 10796Cesium carbonateHCID 221144Chloromethyl propionateHCID 216625422-(1-(2,3-Dimethylphenyl)ethyl)-1H-imidazole

Product 1

HCID 24738940{2-[1-(2,3-Dimethylphenyl)ethyl]-1h-imidazol-1-yl}methyl propionate

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a suspension of the compound of Example 1 (120 mg, 0.6 mmol) and caesium carbonate (731 mg, 1.8 mmol) in acetone (4 ml), under nitrogen, was added chloromethyl propionate (Eur. J. Pharm. Sci: 24; 5; 2005; 433-440, 183 mg, 1.5 mmol) and the reaction mixture was stirred at room temperature for 18 h. The mixture was filtered and the filtrate was concentrated in vacuo.

Workup

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-87da69cc771e476499aa674037b88290
Source dataset
uspto-grants-2009_09
Patent number
US07592362B2

Linked notes

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