Pyridine → HCID 57718409, compound

HRID 734466

Reaction equation

HRID 734466 reaction equation
[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C@@H:9]([C:11]1[NH:12][CH:13]=[CH:14][N:15]=1)[CH3:10].N1C=CC=CC=1.[O:22]=[C:23](Cl)[O:24][C:25](Cl)(Cl)Cl.[CH2:30]([O:34][C:35]1[CH:40]=[CH:39][C:38](CO)=[CH:37][CH:36]=1)[CH2:31][CH2:32][CH3:33]>C(#N)C>[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C@@H:9]([C:11]1[N:15]([C:23]([O:24][CH2:25][C:38]2[CH:39]=[CH:40][C:35]([O:34][CH2:30][CH2:31][CH2:32][CH3:33])=[CH:36][CH:37]=2)=[O:22])[CH:14]=[CH:13][N:12]=1)[CH3:10]

Participants

6

Reactant 4

HCID 1049PyridineHCID 10426DiphosgeneHCID 803464-ButoxybenzenemethanolHCID 24738933Demiditraz

Product 1

HCID 57718409HCID 57718409, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a mixture of the compound of Example 58 (200 mg, 1.0 mmol) and pyridine (177 μl, 2.2 mmol) in anhydrous acetonitrile (3 ml), at 0° C. and under nitrogen, was added diphosgene (132 μl, 1.1 mmol). The mixture was allowed to warm to room temperature and stirred for 10 min, before addition to (4-butoxyphenyl)methanol (198 mg, 1.1 mmol) via syringe. The reaction mixture was stirred at room temperature for 30 min and filtered.

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-04b9cc82d369446cbf7fc50b637f33c3
Source dataset
uspto-grants-2009_09
Patent number
US07592362B2

Linked notes

Loading…