6-fluoro-1H-indazol-5-amine → N-(6-Fluoro-1H-indazol-5-yl)-1,2-dimethyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-1,4,5,6-tetrahydro-3-pyridinecarboxamide
Reaction equation
[CH3:1][N:2]1[C:7](=[O:8])[CH2:6][CH:5]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[C:4]([C:19](O)=[O:20])=[C:3]1[CH3:22].[NH2:23][C:24]1[CH:25]=[C:26]2[C:30](=[CH:31][C:32]=1[F:33])[NH:29][N:28]=[CH:27]2>>[F:33][C:32]1[CH:31]=[C:30]2[C:26]([CH:27]=[N:28][NH:29]2)=[CH:25][C:24]=1[NH:23][C:19]([C:4]1[CH:5]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:16])([F:18])[F:17])=[CH:11][CH:10]=2)[CH2:6][C:7](=[O:8])[N:2]([CH3:1])[C:3]=1[CH3:22])=[O:20]Participants
3
Procedure
The title compound was prepared from the product of Example 41, Step 2 and 5-amino-6-fluoroindazole using the method described in Example 56, Step 3. MS (ES+) m/e 447 [M+H]+
Sources & evidence
- ORD record
- ord-d52f96ce6a384238ab0abd13dc3538f1