2-(4-Iodophenoxy)ethanol → HCID 69059827, compound

HRID 734828

Reaction equation

HRID 734828 reaction equation
[Cl:1][C:2]1[C:3]([C:15]#[CH:16])=[N:4][CH:5]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)[CH:7]=1.I[C:18]1[CH:27]=[CH:26][C:21]([O:22][CH2:23][CH2:24][OH:25])=[CH:20][CH:19]=1>>[Cl:1][C:2]1[C:3]([C:15]#[C:16][C:18]2[CH:27]=[CH:26][C:21]([O:22][CH2:23][CH2:24][OH:25])=[CH:20][CH:19]=2)=[N:4][CH:5]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 35132082-(4-Iodophenoxy)ethanolHCID 86077065HCID 86077065, compound

Product 1

HCID 69059827HCID 69059827, compound

Procedure

The product was prepared analogously to Example 7.1e starting from 3-chloro-5-(4-chlorophenyl)-2-ethynylpyridine and 2-(4-iodophenoxy)ethanol. Yield: 0.48 g (66% of theoretical); C21H15Cl2NO2 (M=384.255); calc.: molpeak (M+H)+384/386/388 (2Cl); found: molpeak (M+H)+: 384/386/388 (2Cl); HPLC-MS: 6.24 minutes (method B).

Workup

  1. customThe product was prepared analogously to Example 7.1e
  2. custom6.24 minutes (method B)

Sources & evidence

ORD record
ord-b6c812566d88441585d846c95170540d
Source dataset
uspto-grants-2009_09
Patent number
US07592358B2

Linked notes

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