2-(4-Iodophenyl)ethan-1-ol → HCID 69057844, compound

HRID 734895

Reaction equation

HRID 734895 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11]([C:14]#[CH:15])=[N:12][CH:13]=2)=[CH:4][CH:3]=1.I[C:17]1[CH:22]=[CH:21][C:20]([CH2:23][CH2:24][OH:25])=[CH:19][CH:18]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[CH:10][C:11]([C:14]#[C:15][C:17]3[CH:22]=[CH:21][C:20]([CH2:23][CH2:24][OH:25])=[CH:19][CH:18]=3)=[N:12][CH:13]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 30407702-(4-Iodophenyl)ethan-1-olHCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridine

Product 1

HCID 69057844HCID 69057844, compound

Procedure

The product was prepared analogously to Example 48.1c from 1.74 g (8.06 mmol) of 5-(4-chlorophenyl)-2-ethynylpyridine and 2.00 g (8.06 mmol) of 2-(4-iodophenyl)ethanol (24 at RT, triethylamine as base and acetonitrile as solvent). Yield: 1.80 g (67% of theoretical); C21H16ClNO (M=333.811); calc.: molpeak (M+H)+:334/336 (Cl); found: molpeak (M+H)+:334/336 (Cl).

Sources & evidence

ORD record
ord-e44bce97461e43f191b1396a4b858b0a
Source dataset
uspto-grants-2009_09
Patent number
US07592358B2

Linked notes

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