HuagongsheHuagongshe Chemistry Print Report · For research reference only
{4-[2-(Diethylamino)ethoxy]phenyl}methanamine → 3-(2-Chloro-4-methylphenyl)propynoic acid-[4-(2-diethylaminoethoxy)phenyl]methylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | {4-[2-(Diethylamino)ethoxy]phenyl}methanamine | HCID 235944 | — |
| Reactant | (2-Chloro-4-trifluoromethylphenyl)propynoic acid | HCID 68817422 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 3-(2-Chloro-4-methylphenyl)propynoic acid-[4-(2-diethylaminoethoxy)phenyl]methylamide | HCID 68816196 | — |
Reaction Steps
Prepared analogously to Example 2.3.f. from [4-(2-diethylaminoethoxy)phenyl]methylamine and (2-chloro-4-trifluoromethylphenyl)propynoic acid. Yield: 60 mg (22% of theory); melting point: 135° C.-138° C.; C23H24ClF3N2O2 (M=452.90); calc.: molecular ion peak (M+H)+: 453/455; found: molecular ion peak (M+H)+: 453/455; Rf value: 0.4 (silica gel, dichloromethane/methanol (9:1)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592373B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-00ab607748f4433d9ace12dca0689b73 |
| Source note | uspto-grants-2009_09 |