3-Chloro-4-nitrophenol → [2-(3-Chloro-4-nitrophenoxy)ethyl]diethylamine

HRID 735091

Reaction equation

HRID 735091 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([OH:11])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].Cl.Cl[CH2:14][CH2:15][N:16]([CH2:19][CH3:20])[CH2:17][CH3:18]>ClCCl.CO>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9])[O:11][CH2:14][CH2:15][N:16]([CH2:19][CH3:20])[CH2:17][CH3:18]

Participants

4

Reactant 2

HCID 102833-Chloro-4-nitrophenolHCID 133631-Chloro-2-(diethylamine)ethane hydrochloride

Product 1

HCID 68816613[2-(3-Chloro-4-nitrophenoxy)ethyl]diethylamine

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Prepared analogously to Example 4.1.a. from 3-chloro-4-nitrophenol and (2-chloroethyl)diethylamine hydrochloride. Yield: 1.25 g (79.5% of theory); C12H17ClN2O3 (M=272.73); calc.: molecular ion peak (M+H)+: 273/275; found: molecular ion peak (M+H)+: 273/275; Rf value: 0.44 (silica gel, dichloromethane/methanol (90:10)).

Workup

  1. customPrepared analogously to Example 4.1.a

Sources & evidence

ORD record
ord-0b2845645be14f609260747be85b6098
Source dataset
uspto-grants-2009_09
Patent number
US07592373B2

Linked notes

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