Morpholine → N-(3-iodophenyl)morpholine-4-carboxamide
Reaction equation
[I:1][C:2]1[CH:3]=[C:4]([N:8]=[C:9]=[O:10])[CH:5]=[CH:6][CH:7]=1.[NH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1>O1CCOCC1>[I:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)=[O:10])[CH:5]=[CH:6][CH:7]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 3-iodophenylisocyanate (0.1 g, 0.41 mmol) and morpholine (0.04 mL, 0.45 mmol) in 2 mL dioxane were heated at 100° C. overnight. The solvent was evaporated and the resulting product was used without purification.
Workup
- customThe solvent was evaporated
- customthe resulting product was used without purification
Sources & evidence
- ORD record
- ord-2ac11e4619694d1fb29660e57b04f049
- Source dataset
- uspto-grants-2009_09
- Patent number
- US07592363B2
Reaction notes
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