3-Isocyanatobenzonitrile → 1-(4-Bromophenethyl)-3-(3-cyanophenyl)-1-methylurea
Reaction equation
Br[C:2]1[CH:7]=C[C:5]([CH2:8][CH2:9][CH2:10][N:11]([CH3:23])[C:12]([NH:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]#[N:22])[CH:16]=2)=[O:13])=[CH:4][CH:3]=1.[Br:24]C1C=CC(CCNC)=CC=1.N(C1C=C(C=CC=1)C#N)=C=O>>[Br:24][C:3]1[CH:2]=[CH:7][C:8]([CH2:9][CH2:10][N:11]([CH3:23])[C:12]([NH:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]#[N:22])[CH:16]=2)=[O:13])=[CH:5][CH:4]=1Participants
4
Procedure
Using a procedure analogous to that used to prepare 22C, 23B (300 mg, 1.4 mmol) was reacted with 3-isocyanatobenzonitrile to yield 23C (406 g, 81%) as a clear oil. MS (ESI) m/z 358.31/360.29 (M+H)+.