3-Fluoro-4-piperazin-1-yl-benzonitrile → 3-Fluoro4-[4-(2-iodo-5-methanesulfonyl-benzoyl)-piperazin-1-yl]-benzonitrile

HRID 736229

Reaction equation

HRID 736229 reaction equation
[I:1][C:2]1[CH:10]=[CH:9][C:8]([S:11]([CH3:14])(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=O.[F:15][C:16]1[CH:17]=[C:18]([CH:21]=[CH:22][C:23]=1[N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1)[C:19]#[N:20]>>[F:15][C:16]1[CH:17]=[C:18]([CH:21]=[CH:22][C:23]=1[N:24]1[CH2:29][CH2:28][N:27]([C:4](=[O:6])[C:3]2[CH:7]=[C:8]([S:11]([CH3:14])(=[O:13])=[O:12])[CH:9]=[CH:10][C:2]=2[I:1])[CH2:26][CH2:25]1)[C:19]#[N:20]

Participants

3

Reactant 2

HCID 5961133-Fluoro-4-piperazin-1-yl-benzonitrileHCID 574452812-Iodo-5-methanesulfonyl-benzoic acid

Product 1

HCID 597935053-Fluoro4-[4-(2-iodo-5-methanesulfonyl-benzoyl)-piperazin-1-yl]-benzonitrile

Procedure

Example CL was prepared in analogy to Example 123 from 2-Iodo-5-methanesulfonyl-benzoic acid (example BQ) and 3-Fluoro-4-piperazin-1-yl-benzonitrile (WO9625414). MS (m/e): 514.0 (M+H+, 100%).

Sources & evidence

ORD record
ord-65d543755f074da78c609326a242580f
Source dataset
uspto-grants-2009_09
Patent number
US07595314B2

Linked notes

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