2-cyclopropyl-1H-imidazole → [5-(2-Cyclopropyl-imidazol-1-yl)-2-morpholin-4-yl-phenyl]-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone

HRID 736235

Reaction equation

HRID 736235 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([N:26]2[CH2:31][CH2:30][O:29][CH2:28][CH2:27]2)=[C:6]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=3)[CH2:12][CH2:11]2)=[O:9])[CH:7]=1.[CH:32]1([C:35]2[NH:36][CH:37]=[CH:38][N:39]=2)[CH2:34][CH2:33]1>>[CH:32]1([C:35]2[N:36]([C:2]3[CH:3]=[CH:4][C:5]([N:26]4[CH2:31][CH2:30][O:29][CH2:28][CH2:27]4)=[C:6]([C:8]([N:10]4[CH2:15][CH2:14][N:13]([C:16]5[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=5)[CH2:12][CH2:11]4)=[O:9])[CH:7]=3)[CH:37]=[CH:38][N:39]=2)[CH2:34][CH2:33]1

Participants

3

Reactant 2

HCID 179423832-cyclopropyl-1H-imidazoleHCID 59793730(5-Bromo-2-morpholin-4-yl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone

Product 1

HCID 68841917[5-(2-Cyclopropyl-imidazol-1-yl)-2-morpholin-4-yl-phenyl]-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanoneYield 16%

Procedure

The title compound was prepared according to the procedure described for example 199 from (5-Bromo-2-morpholin-4-yl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone (compound CR) and 2-Cyclopropyl-1H-imidazole (CAS: 89532-38-7) (16% yield, white solid, MS (m/e): 526.3 (M+H, 100%)

Sources & evidence

ORD record
ord-079f3da0462b4aa58a68ba1f2444ec9f
Source dataset
uspto-grants-2009_09
Patent number
US07595314B2

Linked notes

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