Phenol → 6-(3-Hydroxypent-3-yl)pyridin-2-methanol

HRID 741820

Reaction equation

[C:1]1([OH:7])C=CC=CC=1.[C:8]1(S)C=CC=C[CH:9]=1.Br[C:16]1[N:21]=[C:20]([CH2:22][O:23][Si](C(C)(C)C)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:19]=[CH:18][CH:17]=1.Br[C:42]1C=C(F)C=C(OCC2C=CC(OC)=C(OC)C=2)[CH:43]=1>>[OH:23][C:22]([C:20]1[N:21]=[C:16]([CH2:1][OH:7])[CH:17]=[CH:18][CH:19]=1)([CH2:42][CH3:43])[CH2:8][CH3:9]

Participants

Reactant 4

HCID 996Phenol

HCID 7969Thiophenol

HCID 194269851-Bromo-3-(3,4-dimethoxybenzyloxy)-5-fluorobenzene

HCID 233702372-Bromo-6-(tert-butyldiphenylsiloxy)methylpyridine

Product 1

HCID 194269936-(3-Hydroxypent-3-yl)pyridin-2-methanol

Procedure

Following the procedure described for Phenol 2, Step 2 and for Phenol 7, Step 3, but substituting 6-bromo(O-tert-butyldiphenylsilyl)pyridin-2-methanol form Step 4 for 1-bromo-3-(3,4-dimethoxybenzyloxy)-5-fluorobenzene, the title compound was obtained.

Sources & evidence

ORD record: ord-5323fae251334457994cf16671f58341
Source dataset: uspto-grants-1996_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05552437

Linked notes

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