4-Iodobenzenesulfonyl chloride → [(4-Iodophenyl)sulfonyl]-2-pyridylamine
Reaction equation
[I:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[NH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=1>ClCCl>[I:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
4-Iodo-benzenesulfonyl chloride, (52.3 g, 0.17 mol) was dissolved in dichloromethane (300 ml) and 2-aminopyridine (65 g, 0.69 mol) was added. The solution was stirred at room temperature for 3 days, washed with 2M sulfuric acid (2×200 ml) and water (100 ml), dried with Na2SO4 and evaporated to dryness. Yield 46.9 g (76%).
Workup
- washwashed with 2M sulfuric acid (2×200 ml) and water (100 ml)
- dry with materialdried with Na2SO4
- customevaporated to dryness
Sources & evidence
- ORD record
- ord-0f538395ac604578b0bef07e3781bd11
- Source dataset
- uspto-grants-1996_09
- Patent number
- US05556855
Reaction notes
Loading…