1-Benzyl-4-piperidylamine → HCID 19423581, compound

Reaction equation

[C:1]([C:9]1[C:10]([NH:15][C:16](=[O:21])C(Cl)(Cl)Cl)=[N:11][CH:12]=[CH:13][CH:14]=1)(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:22][CH:23]1[CH2:28][CH2:27][N:26](CC2C=CC=CC=2)[CH2:25][CH2:24]1>>[NH:26]1[CH2:27][CH2:28][CH:23]([N:22]2[CH:1]([C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[C:9]3[CH:14]=[CH:13][CH:12]=[N:11][C:10]=3[NH:15][C:16]2=[O:21])[CH2:24][CH2:25]1

Participants

Reactant 2

HCID 4158521-Benzyl-4-piperidylamine

HCID 19423537HCID 19423537, compound

Product 1

HCID 19423581HCID 19423581, compound

Procedure

In similar way as in Preparation Example 89, the title compound was synthesized from 3-benzoyl-2-trichloroacetylaminopyridine and 4-amino-1-benzylpiperidine.

Workup

customIn similar way as in Preparation Example 89

Sources & evidence

ORD record: ord-f3643ef647104c449bd2ab54d0b8e0e0
Source dataset: uspto-grants-1996_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05556860

Reaction notes

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