HuagongsheHuagongshe Chemistry Print Report · For research reference only
Styrene Oxide → 2-(2-(3-(2-Hydroxy-2-phenylethoxy)phenoxy)ethyl)isoindoline-1,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Styrene Oxide | HCID 7276 | — |
| Reactant | 2-[2-(3-Hydroxy-phenoxy)-ethyl]-isoindole-1,3-dione | HCID 58027534 | — |
| Product | 2-(2-(3-(2-Hydroxy-2-phenylethoxy)phenoxy)ethyl)isoindoline-1,3-dione | HCID 67317562 | — |
Reaction Steps
Alkylation reaction of phenol 24 with styrene oxide gave 2-(2-(3-(2-hydroxy-2-phenylethoxy)phenoxy)ethyl)isoindoline-1,3-dione as yellow oil. Yield (0.85 g, 50%): 1H NMR (400 MHz, CDCl3) δ 7.99 (d, J=7.2 Hz, 1H), 7.41-7.53 (m, 3H), 7.28-7.38 (m, 5H), 7.12-7.16 (m, 1H), 6.60-6.65 (m, 1H), 6.52 (s, 1H), 6.48 (dd, J=8.0, 2.0 Hz, 1H), 4.79-4.82 (m, 1H), 4.19 (t, J=5.4 Hz, 2H), 3.72-3.84 (m, 4H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08829244B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-5e398944ad2441beb58cd66c27aa4a09 |
| Source note | uspto-grants-2014_09 |