Acetonitrile → 3-Hydroxy-3-(3-(2-hydroxy-2-phenylethoxy)phenyl)propanenitrile

HRID 74415

Reaction equation

HRID 74415 reaction equation
[OH:1][CH:2]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:3][O:4][C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=1)[CH:8]=[O:9].[C:19](#[N:21])[CH3:20]>>[OH:9][CH:8]([C:7]1[CH:10]=[CH:11][CH:12]=[C:5]([O:4][CH2:3][CH:2]([OH:1])[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:6]=1)[CH2:20][C:19]#[N:21]

Participants

3

Reactant 2

HCID 6342AcetonitrileHCID 607085333-(2-Hydroxy-2-phenylethoxy)benzaldehyde

Product 1

HCID 673170273-Hydroxy-3-(3-(2-hydroxy-2-phenylethoxy)phenyl)propanenitrile

Procedure

Addition of acetonitrile to 3-(2-hydroxy-2-phenylethoxy)benzaldehyde gave 3-hydroxy-3-(3-(2-hydroxy-2-phenylethoxy)phenyl)propanenitrile as a yellow oil. Yield (0.97 g, crude): MS: 284 [M+1]+.

Sources & evidence

ORD record
ord-f73fb67ab6c04a548fd65f2c3e480400
Source dataset
uspto-grants-2014_09
Patent number
US08829244B2

Linked notes

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