Sulfuric Acid → 4'-(Hydroxymethyl)-[1,1'-Biphenyl]-2-Carboxylic Acid

HRID 744968

Reaction equation

HRID 744968 reaction equation
S(=O)(=O)(O)O.CC1(C)C[O:10][C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[C:18]2[CH:23]=[CH:22][C:21]([CH2:24][OH:25])=[CH:20][CH:19]=2)=N1.[OH-:27].[Na+]>O>[OH:25][CH2:24][C:21]1[CH:22]=[CH:23][C:18]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[C:9]([OH:10])=[O:27])=[CH:19][CH:20]=1

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 110658764,4-Dimethyl-2-(4'hydroxymethylbiphenyl-2-yl)oxazoline

Product 1

HCID 153808804'-(Hydroxymethyl)-[1,1'-Biphenyl]-2-Carboxylic AcidYield 65%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Water (6 ml) and sulfuric acid (3.6 g) were added to 2.0 g (7.11 mmol) of 4,4-dimethyl-2-(4'-hydroxymethylbiphenyl-2-yl)oxazoline, followed by heating under reflux for 30 hours. After the reaction liquid was cooled, it was neutralized with a 10% aqueous solution of sodium hydroxide and extracted with chloroform. After the organic phase was washed with water and dried, it was subjected to vacuum concentration. The residue was purified by silica gel column chromatography (a chloroform/methanol system) to give 1.05 g of the title compound (yield 65%).

Workup

  1. temperatureby heating
  2. temperatureunder reflux for 30 hours
  3. customAfter the reaction liquid
  4. temperaturewas cooled
  5. extractionextracted with chloroform
  6. washAfter the organic phase was washed with water
  7. customdried
  8. concentrationit was subjected to vacuum concentration
  9. customThe residue was purified by silica gel column chromatography (a chloroform/methanol system)

Sources & evidence

ORD record
ord-d558a08b0fd54c15a382ba7ffa8f871a
Source dataset
uspto-grants-1996_09
Patent number
US05559236

Linked notes

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