HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → (2-Chloropyridin-4-yl)-(5-fluoro-2,3-dihydroindol-1-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Chloroisonicotinic acid | HCID 236985 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 5-Fluoroindoline | HCID 2774463 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (2-Chloropyridin-4-yl)-(5-fluoro-2,3-dihydroindol-1-yl)-methanone | HCID 58386590 | — |
Reaction Steps
174 mg (1.27 mmol) 5-fluoro-2,3-dihydro-1H-indole were added to 198 mg (1.26 mmol) 2-chloroisonicotinic acid, 351 μL (2.50 mmol) triethylamine and 434 mg (1.35 mmol) TBTU in 3 mL DMF. The reaction mixture was stirred overnight at RT. Purification was carried out by preparative HPLC. The product fractions were combined and evaporated down i. vac.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08829006B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-5d720ad4a5af4249b03846e9b4bcd2f1 |
| Source note | uspto-grants-2014_09 |