Benzyl Chloride → 3-(4-Fluorophenyl)-4-benzylpiperazin-2-one

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[NH:13][CH2:12][CH2:11][NH:10][C:9]2=[O:14])=[CH:4][CH:3]=1.[CH2:15](Cl)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[N:13]([CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:12][CH2:11][NH:10][C:9]2=[O:14])=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 7503Benzyl Chloride

HCID 131206693-(4-Fluorophenyl)piperazin-2-one

Product 1

HCID 131206703-(4-Fluorophenyl)-4-benzylpiperazin-2-one

Procedure

25 g (0.129 mol) of 3-(4-fluorophenyl)-piperazin-2-one, prepared in accordance with Example 13, are alkylated with 18.1 g (0.143 mol) of benzyl chloride, as described in Example 2.

Sources & evidence

ORD record: ord-1158a0385ba44c34a88864c70e084a09
Source dataset: uspto-grants-1986_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04598079

Reaction notes

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