Acetic Anhydride → HCID 58386747, compound

Reaction equation

[F:1][C:2]1[C:10]([F:11])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][C:5](=[O:12])[NH:6]2.[C:13](OC(=O)C)(=[O:15])[CH3:14]>>[C:13]([N:6]1[C:7]2[C:3](=[C:2]([F:1])[C:10]([F:11])=[CH:9][CH:8]=2)[CH2:4][C:5]1=[O:12])(=[O:15])[CH3:14]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 37310114,5-Difluorooxindole

Product 1

HCID 58386747HCID 58386747, compound

Procedure

2.00 g (11.8 mmol) 4,5-difluoro-1,3-dihydro-indol-2-one I were stirred in 6.62 mL (55.0 mmol) acetic anhydride for 2 h at 150° C. The reaction mixture was added to ice water, the precipitated solid was suction filtered and washed with water. The product was recrystallised from a mixture of water and ethanol, suction filtered and dried.

Workup

filtrationfiltered
washwashed with water
customThe product was recrystallised from a mixture of water and ethanol, suction
filtrationfiltered
customdried

Sources & evidence

ORD record: ord-b6935c47a9e94185b05b01ab8db6d25c
Source dataset: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08829006B2

Reaction notes

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