Methanol → 2H-Indol-2-one, 5-fluoro-1,3-dihydro-3-Methyl-
Reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.[CH3:12]O>[Ni]>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH:5]2[CH3:12]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
3.0 g (20 mmol) 5-fluoro-1,3-dihydro-indol-2-one were stirred with 2.0 g Raney nickel in 50 mL methanol for 1.5 h at 200° C. in an autoclave. The catalyst was filtered off and the filtrate was concentrated to dryness by rotary evaporation. The residue was recrystallised from methanol, suction filtered and dried.
Workup
- filtrationThe catalyst was filtered off
- concentrationthe filtrate was concentrated to dryness by rotary evaporation
- customThe residue was recrystallised from methanol, suction
- filtrationfiltered
- customdried
Sources & evidence
- ORD record
- ord-dcdde16e51c549069ef8eb150764399d
- Source dataset
- uspto-grants-2014_09
- Patent number
- US08829006B2
Reaction notes
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