Thionyl Chloride → HCID 23313625, compound
Reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[CH3:12])[N:8]=[CH:7][N:6](/[CH:13]=[CH:14]/[C:15]([OH:17])=O)[C:5]2=[O:18].S(Cl)(Cl)=O.[N:23]1[CH:28]=[CH:27][CH:26]=[C:25]([CH2:29][CH2:30][CH2:31][CH2:32][NH2:33])[CH:24]=1>>[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[CH3:12])[N:8]=[CH:7][N:6](/[CH:13]=[CH:14]/[C:15]([NH:33][CH2:32][CH2:31][CH2:30][CH2:29][C:25]1[CH:24]=[N:23][CH:28]=[CH:27][CH:26]=1)=[O:17])[C:5]2=[O:18]Participants
4
Procedure
The acid chloride is prepared from (E)-3-(6,7-dimethyl-4-oxo-4H-quinazolin-3-yl]-2-propenoic acid and thionyl chloride as previously described. When this acid chloride is allowed to react with 3-pyridine butanamine under the usual conditions, (E)-3-(6,7-dimethyl-4-oxo-4H-quinazolin-3-yl)-N-[4-(3-pyridinyl)butyl]-2-propenamide is obtained.
Sources & evidence
- ORD record
- ord-f24d0f2444b74f91b10e25d3684ced4c