Putrescine → N-(4-aminobutyl)-aminomethanephosphonic acid monohydrate
Reaction equation
Cl[CH2:2][P:3]([OH:6])(=[O:5])[OH:4].[NH2:7][CH2:8][CH2:9][CH2:10][CH2:11][NH2:12]>O>[OH2:4].[NH2:7][CH2:8][CH2:9][CH2:10][CH2:11][NH:12][CH2:2][P:3]([OH:6])(=[O:5])[OH:4]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Chloromethanephosphonic acid (7.0 g, 53.6 mmoles) and 1,4-diaminobutane (30.0 g, 340 mmoles) were heated under reflux in water (200 cm3) for 20 hours. The water was then distilled off and acetone (110 cm3) was added. The phosphonic acid was filtered off and dried. The crude yield was 9.8 g (91%). A sample was purified by recrystallization from water/ethanol to give N-(4-aminobutyl)-aminomethanephosphonic acid monohydrate as a fine white crystalline solid having a melting point of 258° C.
Workup
- distillationThe water was then distilled off
- additionacetone (110 cm3) was added
- filtrationThe phosphonic acid was filtered off
- customdried
- customA sample was purified by recrystallization from water/ethanol
Sources & evidence
- ORD record
- ord-ef5044f41d464b26979c98549f6d3906
- Source dataset
- uspto-grants-1986_07
- Patent number
- US04600429
Reaction notes
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