N-Cbz-2-amino 1-[di-(t-butyl)methoxy]propane → 2-Amino 1-[di-(t-butyl)methoxy]propane

HRID 746188

Reaction equation

HRID 746188 reaction equation
C([NH:11][CH:12]([CH3:24])[CH2:13][O:14][CH:15]([C:20]([CH3:23])([CH3:22])[CH3:21])[C:16]([CH3:19])([CH3:18])[CH3:17])(OCC1C=CC=CC=1)=O>CO.[Pd]>[NH2:11][CH:12]([CH3:24])[CH2:13][O:14][CH:15]([C:20]([CH3:23])([CH3:22])[CH3:21])[C:16]([CH3:18])([CH3:17])[CH3:19]

Participants

4

Reactant 1

HCID 20201216N-Cbz-2-amino 1-[di-(t-butyl)methoxy]propane

Product 1

HCID 139072462-Amino 1-[di-(t-butyl)methoxy]propane

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

N-Cbz-2-Amino 1-[di-(t-butyl)methoxy]propane is dissolved in CH3OH and hydrogenated over 5% Pd/C in a Paar hydrogenation apparatus. When the reaction is complete the mixture is filtered through Celite and concentrated to yield 2-amino 1-[di-(t-butyl)methoxy]propane.

Workup

  1. filtrationis filtered through Celite
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-ec12328dc9534bbea17ed52667cbb52a
Source dataset
uspto-grants-1986_07
Patent number
US04603011

Linked notes

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