HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoroethyl bromide → 2-(4-Chlorobenzyl)-2-(2-fluoroethyl)malononitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoroethyl bromide | HCID 12982 | — |
| Reactant | 2-((4-Chlorophenyl)methyl)propanedinitrile | HCID 18082 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(4-Chlorobenzyl)-2-(2-fluoroethyl)malononitrile | HCID 22235083 | 24.2% |
Reaction Steps
Using 1.00 g of (4-chlorobenzyl)malononitrile, 10 ml of N,N-dimethylformamide, 0.21 g of sodium hydride (60% in oil), and 0.67 g of 1-bromo-2-fluoroethane, and according to the process described in the Production Example 1, there was obtained 0.30 g of 2-(4-chlorobenzyl)-2-(2-fluoroethyl)malononitrile (the present compound (24)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07402691B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-4729156c536a400a9292f9af85579c5c |
| Source note | uspto-grants-2008_07 |