HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 2-(4-Methoxybenzyl)-2-(3,3,3-trifluoropropyl)malononitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3-Bromo-1,1,1-trifluoropropane | HCID 2725114 | — |
| Reactant | 2-(4-Methoxybenzyl)malononitrile | HCID 2764141 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(4-Methoxybenzyl)-2-(3,3,3-trifluoropropyl)malononitrile | HCID 22235014 | 27.7% |
Reaction Steps
Using 0.39 g of 2-(4-methoxybenzyl)malononitrile, 5 ml of N,N-dimethylformamide, 0.12 g of sodium hydride (60% in oil), and 0.34 g of 1-bromo-3,3,3-trifluoropropane, and according to the process described in the Production Example 1, there was obtained 0.15 g of 2-(4-methoxybenzyl)-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (89)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07402691B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-7bc74f264c974fa9b95d4105bebdbf2c |
| Source note | uspto-grants-2008_07 |