4-Fluoroaniline → [3-(2,6-Difluoro-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-(4-fluoro-phenyl)-amine
Reaction equation
Cl[C:2]1[N:7]=[C:6]2[NH:8][N:9]=[C:10]([C:11]3[C:16]([F:17])=[CH:15][CH:14]=[CH:13][C:12]=3[F:18])[C:5]2=[CH:4][N:3]=1.[F:19][C:20]1[CH:26]=[CH:25][C:23]([NH2:24])=[CH:22][CH:21]=1>>[F:18][C:12]1[CH:13]=[CH:14][CH:15]=[C:16]([F:17])[C:11]=1[C:10]1[C:5]2[C:6](=[N:7][C:2]([NH:24][C:23]3[CH:25]=[CH:26][C:20]([F:19])=[CH:21][CH:22]=3)=[N:3][CH:4]=2)[NH:8][N:9]=1Participants
3
Procedure
The compound was prepared from 6-chloro-3-(2,6-difluoro-phenyl)-1H-pyrazolo[3,4-d]pyrimidine (Example 12) and 4-fluoroaniline (Aldrich) in an analogous manner as described in Example 32 (160° C.). Filtration and washing with 2-propanol after the reaction gave the title product (59%). MS (M+H)+, 342.1
Workup
- customas described in Example 32 (160° C.)
- filtrationFiltration
- washwashing with 2-propanol after the reaction