4-(Pyrrolidin-1-yl)butan-1-amine → 3-(4-Bromo-2,3,6-trifluoro-benzyloxy)-5-[3-(4-pyrrolidin-1-yl-butyl)-ureido]-isothiazole-4-carboxylic Acid Amide

HRID 750615

Reaction equation

HRID 750615 reaction equation
C1([O:7][C:8](=O)[NH:9][C:10]2[S:14][N:13]=[C:12]([O:15][CH2:16][C:17]3[C:22]([F:23])=[CH:21][C:20]([Br:24])=[C:19]([F:25])[C:18]=3[F:26])[C:11]=2[C:27](=[O:29])[NH2:28])C=CC=CC=1.[N:31]1([CH2:36][CH2:37][CH2:38][CH2:39][NH2:40])[CH2:35][CH2:34][CH2:33][CH2:32]1>>[Br:24][C:20]1[CH:21]=[C:22]([F:23])[C:17]([CH2:16][O:15][C:12]2[C:11]([C:27]([NH2:28])=[O:29])=[C:10]([NH:9][C:8]([NH:40][CH2:39][CH2:38][CH2:37][CH2:36][N:31]3[CH2:35][CH2:34][CH2:33][CH2:32]3)=[O:7])[S:14][N:13]=2)=[C:18]([F:26])[C:19]=1[F:25]

Participants

3

Reactant 2

HCID 27627624-(Pyrrolidin-1-yl)butan-1-amineHCID 86588929[3-(4-Bromo-2,3,6-trifluoro-benzyloxy)4-carbamoyl-isothiazol-5-yl]-carbamic acid phenyl ester

Product 1

HCID 100990543-(4-Bromo-2,3,6-trifluoro-benzyloxy)-5-[3-(4-pyrrolidin-1-yl-butyl)-ureido]-isothiazole-4-carboxylic Acid Amide

Procedure

The title compound was prepared from [3-(4-bromo-2,3,6-trifluoro-benzyloxy)-4-carbamoyl-isothiazol-5-yl]-carbamic acid phenyl ester and 4-pyrrolidin-1-yl-butylamine by the procedure analogous to Example 1. MS (APCl, m/z): 550 and 552 [M+H]+.

Sources & evidence

ORD record
ord-36d305305f7e43bd9d38a7d7482bd826
Source dataset
uspto-grants-2008_07
Patent number
US07405218B2

Linked notes

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