4-Fluorobenzyl bromide → {3-[2-(4-Fluoro-benzyl)-1,1-dioxo-2,3-dihydro-1h-1lambda6-benzo[d]isothiazol-3-yl]-5-methoxy-indol-1-yl}-acetic acid

HRID 750666

Reaction equation

HRID 750666 reaction equation
C([O:5][C:6](=[O:30])[CH2:7][N:8]1[C:16]2[C:11](=[CH:12][C:13]([O:17][CH3:18])=[CH:14][CH:15]=2)[C:10]([CH:19]2[C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=3[S:21](=[O:29])(=[O:28])[NH:20]2)=[CH:9]1)(C)(C)C.[F:31][C:32]1[CH:39]=[CH:38][C:35]([CH2:36]Br)=[CH:34][CH:33]=1>>[F:31][C:32]1[CH:39]=[CH:38][C:35]([CH2:36][N:20]2[CH:19]([C:10]3[C:11]4[C:16](=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[CH:12]=4)[N:8]([CH2:7][C:6]([OH:5])=[O:30])[CH:9]=3)[C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=3[S:21]2(=[O:28])=[O:29])=[CH:34][CH:33]=1

Participants

3

Reactant 2

HCID 680214-Fluorobenzyl bromideHCID 67316901[3-(1,1-Dioxo-2,3-dihydro-1h-1lambda6-benzo[d]isothiazol-3-yl)-5-methoxy-indol-1-yl]-acetic acid tert-butyl ester

Product 1

HCID 59753809{3-[2-(4-Fluoro-benzyl)-1,1-dioxo-2,3-dihydro-1h-1lambda6-benzo[d]isothiazol-3-yl]-5-methoxy-indol-1-yl}-acetic acid

Procedure

The title compound was prepared by the method described for example 14 using the product from example 4, step c) and 4-fluorobenzyl bromide. MS: ESI (negative): 479 (M−H).

Sources & evidence

ORD record
ord-ef2766eb7e4b44a29f8dfb30190446b0
Source dataset
uspto-grants-2008_07
Patent number
US07405215B2

Linked notes

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