Tricyclo(3.3.1.13,7)dec-1-ylmethylamine → (+/-)-1-(1-Adamantylmethyl)-4-(hydroxymethyl)-4-isobutylimidazolidin-2-one

HRID 75167

Reaction equation

HRID 75167 reaction equation
C(O[C:6]([NH:8][C:9]([CH2:17]O)([CH2:13][CH:14]([CH3:16])[CH3:15])[C:10]([OH:12])=O)=[O:7])(C)(C)C.[NH2:19][CH2:20][C:21]12[CH2:30][CH:25]3[CH2:26][CH:27]([CH2:29][CH:23]([CH2:24]3)[CH2:22]1)[CH2:28]2>>[C:21]12([CH2:20][N:19]3[CH2:17][C:9]([CH2:10][OH:12])([CH2:13][CH:14]([CH3:15])[CH3:16])[NH:8][C:6]3=[O:7])[CH2:28][CH:27]3[CH2:26][CH:25]([CH2:24][CH:23]([CH2:29]3)[CH2:22]1)[CH2:30]2

Participants

3

Reactant 2

HCID 86625Tricyclo(3.3.1.13,7)dec-1-ylmethylamineHCID 78067738(+/-)-2-(Tert-butoxycarbonylamino)-2-(hydroxymethyl)-4-methylpentanoic acid

Product 1

HCID 68472064(+/-)-1-(1-Adamantylmethyl)-4-(hydroxymethyl)-4-isobutylimidazolidin-2-one

Procedure

The title compound was prepared following procedures analogous to those described in Example 27 using (±)-2-(tert-butoxycarbonylamino)-2-(hydroxymethyl)-4-methylpentanoic acid and 1-(aminomethyl)adamantane. MS m/z=321.

Sources & evidence

ORD record
ord-be24594330af48f5870c8035a084a492
Source dataset
uspto-grants-2014_09
Patent number
US08835426B2

Linked notes

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