Alpha-Aminobutyric Acid → 2-(Acetylamino)butanoic acid

HRID 7535

Reaction equation

HRID 7535 reaction equation
[NH2:1][CH:2]([CH2:6][CH3:7])[C:3]([OH:5])=[O:4].[C:8](OC(=O)C)(=[O:10])[CH3:9]>C(O)(=O)C>[C:8]([NH:1][CH:2]([CH2:6][CH3:7])[C:3]([OH:5])=[O:4])(=[O:10])[CH3:9]

Participants

4

Reactant 2

HCID 6657Alpha-Aminobutyric AcidHCID 7918Acetic Anhydride

Product 1

HCID 3061072-(Acetylamino)butanoic acid

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
100 °C

Procedure

163 g (1.58 mol) 2-aminobutanoic acid are dissolved in acetic acid, and 242 g (2.37 mol) acetic anhydride are added dropwise. The mixture is stirred for 2 h at 100° C. until completion of reaction, then the solution evaporated to dryness in vacuo. The solid residue is suspended in ethyl acetate, filtered and washed with diethyl ether.

Workup

  1. customthe solution evaporated to dryness in vacuo
  2. filtrationfiltered
  3. washwashed with diethyl ether

Sources & evidence

ORD record
ord-4825907718a34102b76de664069c39ba
Source dataset
uspto-grants-2006_08
Patent number
US07087605B2

Linked notes

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