Cyclopentanecarbonyl chloride → N-[1-(3-tert-butyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]cyclopentanecarboxamide

HRID 7545

Reaction equation

HRID 7545 reaction equation
[NH2:1][CH:2]([C:5]1[C:6](=[O:15])[NH:7][C:8]([C:11]([CH3:14])([CH3:13])[CH3:12])=[N:9][N:10]=1)[CH2:3][CH3:4].[CH:16]1([C:21](Cl)=[O:22])[CH2:20][CH2:19][CH2:18][CH2:17]1>>[C:11]([C:8]1[NH:7][C:6](=[O:15])[C:5]([CH:2]([NH:1][C:21]([CH:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)=[O:22])[CH2:3][CH3:4])=[N:10][N:9]=1)([CH3:14])([CH3:13])[CH3:12]

Participants

3

Reactant 2

HCID 78284Cyclopentanecarbonyl chlorideHCID 1355940906-(1-Aminopropyl)-3-tert-butyl-1,2,4-triazin-5(4h)-one

Product 1

HCID 135752563N-[1-(3-tert-butyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]cyclopentanecarboxamide

Procedure

In analogy to the procedure for Example 36A, 110 mg (0.50 mmol) 6-(1-aminopropyl)-3-tert-butyl-1,2,4-triazin-5(4H)-one, 70 mg (0.50 mmol) cyclopentanecarbonyl chloride and proportionate amounts of the other reagents are used. The crude product is used in the next step without further purification.

Workup

  1. customThe crude product is used in the next step without further purification

Sources & evidence

ORD record
ord-b46f015255f1488ebf4026b731b6fb22
Source dataset
uspto-grants-2006_08
Patent number
US07087605B2

Linked notes

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