4-(4-Methylpiperazin-1-yl)aniline → 1-(4-(4-Methylpiperazin-1-yl)phenyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

HRID 75459

Reaction equation

HRID 75459 reaction equation
[CH:1]1([NH:4][C:5]([NH:7][C:8]2[CH:13]=[CH:12][C:11]([B:14]3[O:18][C:17]([CH3:20])([CH3:19])[C:16]([CH3:22])([CH3:21])[O:15]3)=[CH:10][CH:9]=2)=[O:6])[CH2:3][CH2:2]1.[CH3:23][N:24]1[CH2:29][CH2:28][N:27]([C:30]2C=CC(N)=[CH:32][CH:31]=2)[CH2:26][CH2:25]1>>[CH3:23][N:24]1[CH2:29][CH2:28][N:27]([C:30]2[CH:3]=[CH:2][C:1]([NH:4][C:5]([NH:7][C:8]3[CH:13]=[CH:12][C:11]([B:14]4[O:18][C:17]([CH3:19])([CH3:20])[C:16]([CH3:21])([CH3:22])[O:15]4)=[CH:10][CH:9]=3)=[O:6])=[CH:32][CH:31]=2)[CH2:26][CH2:25]1

Participants

3

Reactant 2

HCID 7372534-(4-Methylpiperazin-1-yl)anilineHCID 44119149N-Cyclopropyl-N'-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

Product 1

HCID 667500921-(4-(4-Methylpiperazin-1-yl)phenyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

Procedure

A procedure analogous to that used for the preparation of 1-cyclopropyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea was used, using 4-(4-methylpiperazin-1-yl)aniline as the amine component.

Sources & evidence

ORD record
ord-26d42be9a98745819b01a247ad4d73b8
Source dataset
uspto-grants-2014_09
Patent number
US08835429B2

Linked notes

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