3-Methoxybenzaldehyde → N-(1H-indazol-5-yl)-2-(3-methoxybenzyl)-2-azabicyclo[2.2.2]octan-4-amine

HRID 75704

Reaction equation

HRID 75704 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([NH:10][C:11]34[CH2:18][CH2:17][CH:14]([CH2:15][CH2:16]3)[NH:13][CH2:12]4)=[CH:7][CH:8]=2)[CH:3]=[N:2]1.[CH3:19][O:20][C:21]1[CH:22]=[C:23]([CH:26]=[CH:27][CH:28]=1)[CH:24]=O>>[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([NH:10][C:11]34[CH2:16][CH2:15][CH:14]([CH2:17][CH2:18]3)[N:13]([CH2:24][C:23]3[CH:26]=[CH:27][CH:28]=[C:21]([O:20][CH3:19])[CH:22]=3)[CH2:12]4)=[CH:7][CH:8]=2)[CH:3]=[N:2]1

Participants

3

Reactant 2

HCID 115693-MethoxybenzaldehydeHCID 67234936N-(1H-indazol-5-yl)-2-azabicyclo[2.2.2]octan-4-amine

Product 1

HCID 53245858N-(1H-indazol-5-yl)-2-(3-methoxybenzyl)-2-azabicyclo[2.2.2]octan-4-amine

Procedure

Reaction of Intermediate 26 with 3-methoxybenzaldehyde affords the title compound.

Sources & evidence

ORD record
ord-18129cb107d14d8aa796bd853e2926c2
Source dataset
uspto-grants-2014_09
Patent number
US08835457B2

Linked notes

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