HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexyl isocyanate → 3-[4-(3-Cyclohexyl-ureido)-phenyl]-isoxazole-5-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexyl isocyanate | HCID 18502 | — |
| Reactant | Potassium Bromide | HCID 253877 | — |
| Reactant | Ethyl 3-(4-aminophenyl)isoxazole-5-carboxylate | HCID 53407704 | — |
| Reactant | 3-[4-(3-Phenyl-ureido)-phenyl]-isoxazole-5-carboxylic acid ethyl ester | HCID 67352240 | — |
| Product | 3-[4-(3-Cyclohexyl-ureido)-phenyl]-isoxazole-5-carboxylic acid ethyl ester | HCID 67354653 | 75% |
Reaction Steps
The title compound was prepared from 3-(4-amino-phenyl)-isoxazol-5-carboxylic acid ethyl ester and cyclohexyl isocyanate by same procedure as set forth for the preparation of 3-[4-(3-phenyl-ureido)-phenyl]-isoxazole-5-carboxylic acid ethyl ester and was obtained in 75% yield. Mass (ES+), 358 (M++1); IR (KBr): 3304, 2928, 2852, 1731, 1634, 1570 (br); 1H NMR (DMSO-d6) δ: 1.33 (t, 3H), 1.14-1.81 (4×m, 10H), 3.45 (br, 1H), 4.37 (q, 2H), 6.18 (d, 1H), 7.50 (d, 2H), 7.60 (s, 1H), 7.79 (s, 1H), 7.8.1 (d, 2H), 8.59 (s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08835428B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-53f4d7ff59f245f59e1bfcfa30d2f0b4 |
| Source note | uspto-grants-2014_09 |