Bindarit → 2-methyl-2-{[1-(1,2,3,4-tetrahydronaphth-1-yl)-1H-indazol-3-yl]methoxy}-propanoic acid

HRID 76117Notes

Reaction equation

HRID 76117 reaction equation
[CH3:1][C:2]([O:7][CH2:8][C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]([CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[N:10]=1)([CH3:6])[C:3]([OH:5])=[O:4].Cl[CH:26]1[C:35]2C(=CC=CC=2)CC[CH2:27]1>>[CH3:6][C:2]([O:7][CH2:8][C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]([CH:18]2[C:19]3[C:24](=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:35][CH2:26][CH2:27]2)[N:10]=1)([CH3:1])[C:3]([OH:5])=[O:4]

Participants

3

Reactant 2

HCID 71354BindaritHCID 1887171-Chloro-1,2,3,4-tetrahydronaphthalene

Product 1

HCID 442171642-methyl-2-{[1-(1,2,3,4-tetrahydronaphth-1-yl)-1H-indazol-3-yl]methoxy}-propanoic acid

Procedure

The product was prepared according to the procedure described in Example 6b), using as starting material 2-methyl-2-[(1-benzyl-1H-indazol-3-yl)methoxy]propanoic acid as starting material and 1-chloro-1,2,3,4-tetrahydronaphthalene as reagent.

Workup

  1. customThe product was prepared

Sources & evidence

ORD record
ord-aae1fc72976c48e9973caadd6feac10c
Source dataset
uspto-grants-2014_09
Patent number
US08835481B2

Reaction notes

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