Ethanol → 2-Oxopyrrolidine-3-carboxylic acid

HRID 76181

Reaction equation

HRID 76181 reaction equation
C(OC([N:6]1[CH2:10][CH2:9][CH2:8][C:7]1=[O:11])=O)C.[OH-:12].[Na+].C[CH2:15][OH:16]>>[O:11]=[C:7]1[CH:8]([C:15]([OH:16])=[O:12])[CH2:9][CH2:10][NH:6]1

Participants

4

Reactant 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 234959Ethyl 2-oxopyrrolidine-1-carboxylate

Product 1

HCID 134743702-Oxopyrrolidine-3-carboxylic acid

Procedure

To 0.50 g (3.18 mmol) 2-oxo-pyrollidine-carboxylic acid ethyl ester in 10 mL EtOH are added 5 mL aq. NaOH (1M) solution. The reaction mixture is stirred at r.t. for 3 h. The EtOH is removed in vacuo and the residue is diluted with water and acidified with aq. HCl (2M) solution. The resulting precipitate is filtered and dried.

Workup

  1. customThe EtOH is removed in vacuo
  2. additionthe residue is diluted with water
  3. filtrationThe resulting precipitate is filtered
  4. customdried

Sources & evidence

ORD record
ord-eb7275050f334e848da4cf494465570b
Source dataset
uspto-grants-2014_09
Patent number
US08835472B2

Linked notes

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